VRTX

Vertex Pharmaceuticals Incorporated
NasdaqGSUSDEQUITY Healthcare DELAYED
Last price
548.05
▲ 7.79 (1.44%)
MARKET ·

Price

Open
539.60
Prev close
540.26
Day high
555.31
Day low
540.70
Volume
940.13K
Market cap
$138.91B
P/E (TTM)
31.96
52W range
374.17 – 555.32

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
+8.36% +9.7%
1M
+15.84% +12.1%
3M
+26.41% +23.3%
6M
+14.92% +3.9%
YTD
+20.89% +8.6%
1Y
+38.97% +19.0%
3Y
+59.59% -14.6%
5Y

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Fundamentals

TTM · reported
Market cap$138.91B
Enterprise value$133.03B
Revenue (TTM)$12.59B
Gross profit$6.92B
EBITDA$5.10B
Net income$4.41B
EPS (TTM)$17.15
Free cash flow$2.63B
Total cash$7.85B
Total debt$1.98B
Book value / share$79.92
Shares outstanding253.46M
Float252.68M
Short % of float1.76%
Dividend yield
Beta (5Y)0.31

Valuation & profitability ratios

Account required
Trailing P/E31.96
Forward P/E24.92
PEG ratio1.91
Price / sales
Price / book6.86
EV / revenue10.57
EV / EBITDA26.08
Gross margin54.96%
Operating margin38.05%
Profit margin35.00%
Return on equity23.54%
Return on assets11.93%
Debt / equity9.77
Current ratio3.19
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

Annual · as reported
Last 4 fiscal years
Line item2025202420232022
Total revenue$12.00B$11.02B$9.87B$8.93B
Cost of revenue$0$0$0$0
Gross profit$0$0$0$0
R&D
SG&A
Operating income
Pre-tax income
Tax provision$0$0$0$0
Net income$3.95B-$535.60M$3.62B$3.32B
EBIT$0$0$0$0

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 4.754.73 -0.3%
Mar 2026 4.314.47 +3.8%
Dec 2025 5.155.03 -2.3%
Sep 2025 4.584.80 +4.9%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter 4.91 13 $3.39B +10.3%
Next quarter 4.92 12 $3.49B +9.6%
Current year 19.03 14 $13.19B +9.9%
Next year 21.84 14 $14.59B +10.6%

Analyst targets & ownership

Account required
Mean target$563.12
High target$672.00
Low target$350.00
Implied upside2.75%
Analyst count25
ConsensusBUY
Strong buy / Buy4 / 19
Hold4
Sell / Strong sell1 / 1
Held by insiders0.21%
Held by institutions98.13%
Institutions holding2.44K
Free account required

Price targets, consensus spread, insider and institutional ownership.

Insider net activity

6m · Form 4 rollup
Net shares
-77.95K
Net selling
Buy transactions
8
68.31K shares
Sell transactions
31
146.26K shares
Net transactions
+39
Buys less sells
Sell : buy shares
2.1 : 1
Mixed
Insider-held shares
532.27K
Total on file
Bought 68.31KSold 146.26K

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Jul 21, 26
TATSIS OURANIA
Officer
STOCK 8.25K $0 Direct
Jul 21, 26
SACHDEV AMIT
Officer
STOCK 8.25K $0 Direct
Jul 2, 26
MCKECHNIE DUNCAN J.
Officer
SELL 1.54K $799.78K Direct
Jul 2, 26
TATSIS OURANIA
Officer
SELL 1.50K $787.49K Direct
Jul 1, 26
LIU JOY
Officer
SELL 828 $416.24K Direct
Jun 26, 26
BOZIC CARMEN
Officer
SELL 596 $287.57K Direct
Jun 18, 26
BOZIC CARMEN
Officer
SELL 1.02K $471.41K Direct
Jun 15, 26
BOZIC CARMEN
Officer
SELL 4.06K $1.83M Direct
Jun 5, 26
BOZIC CARMEN
Officer
SELL 1.75K $785.25K Direct
Jun 1, 26
LIU JOY
Officer
SELL 828 $364.25K Direct
May 29, 26
BOZIC CARMEN
Officer
SELL 1.97K $888.30K Direct
May 15, 26
BUNNAGE MARK E.
Officer
SELL 33 $14.96K Direct
May 15, 26
BOZIC CARMEN
Officer
SELL 1.35K $613.97K Direct
May 12, 26
BOZIC CARMEN
Officer
SELL 6.99K $3.14M Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

10 reporting
NameRelationShares heldLatest
ALTSHULER DAVID
Officer 34.48K Stock Award(Grant)
ARBUCKLE STUART A
Chief Operating Officer 100.75K Stock Award(Grant)
ATKINSON EDWARD MORROW III
Chief Technology Officer 18.43K Sale
KEWALRAMANI RESHMA
Chief Executive Officer 98.28K Sale
LEIDEN JEFFREY M
Officer and Director 38.78K Stock Award(Grant)
LIU JOY
Officer 19.13K Sale
SACHDEV AMIT
Officer 74.03K Stock Award(Grant)
SACHS BRUCE I
Director 45.00K Purchase
TATSIS OURANIA
Officer 53.57K Stock Award(Grant)
WAGNER CHARLES F JR
Chief Operating Officer 48.79K Stock Award(Grant)

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
528.56
+3.69% from price
SMA 20
505.57
+8.40% from price
SMA 50
490.86
+11.65% from price
SMA 100
463.85
+18.15% from price
SMA 200
459.97
+19.15% from price
EMA 12
523.65
+4.66% from price
EMA 26
507.69
+7.95% from price
EMA 50
492.63
+11.25% from price
RSI (14)
67.0
Neutral
MACD (12,26,9)
15.96
Hist 4.46
ATR (14)
17.81
3.25% of price
Realised vol 30D
29.3%
Annualised
Bollinger upper
556.47
20, 2σ
Bollinger lower
454.68
20, 2σ
50 / 200 cross
Golden
490.86 vs 459.97
Trend bias
Above 200
+19.15%

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.47
Less volatile than market
Correlation to SPY
0.21
Largely independent
Realised vol 30D
29.3%
Annualised
Market vol 1Y
12.9%
SPY, annualised
Max drawdown 1Y
-15.2%
Peak to trough
Max drawdown 5Y
-29.1%
Peak to trough
ATR 14
17.81
3.25% of price
Beta (reported)
0.31
5Y monthly, from filing

Unusual options activity

Account required
Flagged1
Total notional$79.38K
Call notional$79.38K
Put notional$0
Tiltcall-weighted
Likely opening1 of 1
SideStrikeExpiryVolumeOpen int. Vol / OINotionalIV PrintScore
CALL 565.00 Aug 28, 26
6d
162 159 1.0× $79.38K 49% mid
40
How this is calculated, and what it cannot see

A contract is flagged when today's volume approaches or exceeds its open interest, the position is worth at least $40,000, and at least 150 contracts changed hands. Open interest is what was outstanding at yesterday's close, so volume above it means the flow cannot all be closing — something is being opened.

The score weights four things: volume against open interest, dollar notional, volume against the rest of that chain, and where the last print sat inside the bid/ask spread.

What it cannot see. Volume here is a daily total, so ten small orders and one large one are indistinguishable — this is not block or sweep detection, which needs exchange-level time and sales. The print column compares the last trade to the current quote, which is a proxy for who was the aggressor, not a tagged flag. Quotes are delayed. A single large trade can be a hedge, a roll, or one leg of a spread, and none of those mean what a naked directional bet would mean.

Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Options analytics

Account required
Put / call volume
0.98
Call-heavy session
Put / call open interest
2.32
Positioning, not flow
Max pain
500.00
-8.8% from spot
ATM implied vol
42.7%
Nearest strike to spot
Skew (10% OTM)
+37.3%
Puts bid over calls
Call volume
325
Contracts, this expiry
Put volume
319
Contracts, this expiry
Heaviest call OI
565.00
159 contracts
Heaviest put OI
330.00
785 contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Options chain

Account required
ExpirySpot 548.05
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.