IONS

Ionis Pharmaceuticals, Inc.
NasdaqGSUSDEQUITY Healthcare DELAYED
Last price
43.30
▼ 0.20 (0.46%)
MARKET · —

Price

1D — H — L — Range — Vol —
Drag pan · Pinch zoom · Hold crosshair · pick a tool then drag to draw
Open
44.93
Prev close
43.50
Day high
44.67
Day low
43.18
Volume
2.19M
Market cap
$7.31B
P/E (TTM)
—
52W range
42.63 – 86.74

Day trading desk

Current session · delayed
Gap from prior close
+3.29%
Prior close 43.50
VWAP
43.96
-1.50% from price
Relative volume
0.97×
Normal
Session range
12.33%
40.00 – 44.93
Position in range
67%
Mid range
ATR (14D)
1.83
4.22% of price
Prior day high
43.96
PDH
Prior day low
42.63
PDL
Bid / ask spread
—
Quote not published
Session volume
3.65M
Avg 3.77M

VWAP and the session figures are computed from the delayed intraday series on this page, so they lag the live tape and will not match a broker's real-time VWAP exactly. Turn on Prior day H/L/C, Opening range and Volume profile in the chart's Studies menu to see these levels drawn on price.

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
-4.12% -6.1%
1M
-24.26% -25.4%
3M
-47.90% -52.4%
6M
-40.45% -58.6%
YTD
-44.38% -58.6%
1Y
-36.37% -52.8%
3Y
-3.00% -85.3%
5Y
— —

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Unusual options activity

Account required
Nothing crossed the thresholds in the expiries we scanned.
That is the normal state — most contracts trade well inside their existing open interest.
Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Free account

5 more panels on IONS open with an account.

Options chains and analytics, valuation ratios, insider filings, analyst targets and ownership. No card, no trial, nothing to cancel.

Insider net activity

6m · Form 4 rollup
Net shares
+2.69K
Net buying
Buy transactions
17
363.06K shares
Sell transactions
20
360.37K shares
Net transactions
+37
Buys less sells
Sell : buy shares
1.0 : 1
Mixed
Insider-held shares
1.01M
Total on file
Bought 363.06KSold 360.37K

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Jul 31, 26
HAYDEN MICHAEL REUBEN
Director
BUY 20.00K $1.06M Indirect
Jul 15, 26
BERTHELSEN SPENCER R
Director
— 5.22K — Direct
Jul 15, 26
HERMAN JOAN E
Director
— 5.22K — Direct
Jul 7, 26
KORDASIEWICZ HOLLY B
Officer
SELL 362 $30.52K Direct
Jul 7, 26
DIAZ ALLENE M.
Director
SELL 10.11K $863.64K Direct
Jul 7, 26
DIAZ ALLENE M.
Director
CONVERSION 10.11K $476.33K Direct
Jul 7, 26
BENNETT C FRANK
Officer
SELL 20.54K $1.74M
Jul 1, 26
KLEIN JOSEPH S III
Director
SELL 11.52K $910.42K Direct
Jul 1, 26
KLEIN JOSEPH S III
Director
CONVERSION 11.52K $460.03K Direct
Jun 26, 26
BAROLDI JOSEPH
Officer
SELL 5.63K $451.70K Indirect
Jun 26, 26
BAROLDI JOSEPH
Officer
CONVERSION 5.63K $277.18K Indirect
Jun 26, 26
SCHNEIDER EUGENE
Officer
SELL 26.00K $2.11M Direct
Jun 26, 26
SCHNEIDER EUGENE
Officer
CONVERSION 26.00K $1.58M Direct
Jun 26, 26
O'NEIL PATRICK R
General Counsel
SELL 3.07K $245.52K Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

10 reporting
NameRelationShares heldLatest
BAROLDI JOSEPH
Officer — Sale
BENNETT C FRANK
Officer — Sale
BERTHELSEN SPENCER R
Director 161.30K Conversion of Exercise of derivative security
BIRCHLER BRIAN
Officer 67.50K Sale
GEARY RICHARD S
Officer 59.66K Sale
HAYDEN MICHAEL REUBEN
Director — Purchase
HOUGEN ELIZABETH L
Chief Financial Officer 82.66K Sale
MONIA BRETT P
Chief Executive Officer 245.57K Sale
O'NEIL PATRICK R
General Counsel 61.47K Sale
SCHNEIDER EUGENE
Officer 77.11K Sale

Fundamentals

TTM · reported
Market cap$7.31B
Enterprise value$7.40B
Revenue (TTM)$874.09M
Gross profit$-60.60M
EBITDA$-579.48M
Net income$-565.17M
EPS (TTM)$-3.52
Free cash flow$-346.76M
Total cash$2.10B
Total debt$2.19B
Book value / share$2.66
Shares outstanding166.18M
Float164.82M
Short % of float16.65%
Dividend yield0.00%
Beta (5Y)0.38

Valuation & profitability ratios

Account required
Trailing P/E—
Forward P/E-39.56
PEG ratio27.33
Price / sales—
Price / book16.57
EV / revenue8.47
EV / EBITDA-12.77
Gross margin-6.93%
Operating margin-38.18%
Profit margin-64.66%
Return on equity-105.50%
Return on assets-12.43%
Debt / equity497.80
Current ratio7.89
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

As reported · 5 years · 5 quarters
Blank means not reported, not zero
Line item2025202420232022YoY
Total revenue $943.71M$705.14M$787.65M$587.37M +33.8%
Operating revenue $943.71M$705.14M$787.65M$587.37M +33.8%
Cost of revenue $15.91M$11.21M$9.13M$14.12M +41.9%
Gross profit $927.80M$693.92M$778.51M$573.25M +33.7%
Research & development $915.62M$901.53M$899.63M$833.15M +1.6%
Selling, general & admin $393.90M$267.50M$232.62M$150.29M +47.3%
Total operating expense $1.31B$1.17B$1.13B$983.44M +12.0%
Operating income -$381.72M-$475.11M-$353.73M-$410.19M +19.7%
Net interest income -$90.58M-$90.46M-$81.46M-$8.12M -0.1%
Pre-tax income -$379.60M-$460.07M-$333.96M-$257.99M +17.5%
Tax provision $1.79M-$6.17M$32.32M$11.74M +128.9%
Net income -$381.39M-$453.90M-$366.29M-$269.72M +16.0%
Net income to common -$381.39M-$453.90M-$366.29M-$269.72M +16.0%
Basic EPS -2.38-3.04-2.56-1.90 +21.7%
Diluted EPS -2.38-3.04-2.56-1.90 +21.7%
EBIT -$295.32M-$375.71M-$252.51M-$249.86M +21.4%
EBITDA -$272.63M-$353.72M-$230.01M-$227.76M +22.9%
Basic shares 160.01M149.51M143.19M141.85M +7.0%
Diluted shares 160.01M149.51M143.19M141.85M +7.0%

Options analytics

Account required
Put / call volume
7.28
Put-heavy session
Put / call open interest
4.57
Positioning, not flow
Max pain
80.00
+81.8% from spot
ATM implied vol
3.1%
Nearest strike to spot
Skew (10% OTM)
0.0%
Calls bid over puts
Call volume
426
Contracts, this expiry
Put volume
3.10K
Contracts, this expiry
Heaviest call OI
87.50
34 contracts
Heaviest put OI
80.00
200 contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 -0.88-0.42 +51.7%
Mar 2026 -0.78-0.30 +60.9%
Dec 2025 -1.22-1.15 +5.6%
Sep 2025 -1.05-0.61 +41.8%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter -0.92 8 $185.50M +18.2%
Next quarter -0.89 8 $240.74M +18.6%
Current year -2.70 10 $919.55M -2.6%
Next year -1.11 10 $1.36B +48.4%

Analyst targets & ownership

Account required
Mean target$83.64
High target$105.00
Low target$54.00
Implied upside93.16%
Analyst count22
ConsensusBUY
Strong buy / Buy9 / 9
Hold5
Sell / Strong sell0 / 0
Held by insiders0.61%
Held by institutions110.37%
Institutions holding719
Free account required

Price targets, consensus spread, insider and institutional ownership.

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
44.34
-2.34% from price
SMA 20
46.73
-5.85% from price
SMA 50
53.41
-17.61% from price
SMA 100
62.25
-30.44% from price
SMA 200
70.05
-37.19% from price
EMA 12
45.23
-4.26% from price
EMA 26
48.55
-10.81% from price
EMA 50
53.01
-18.32% from price
RSI (14)
32.7
Neutral
MACD (12,26,9)
-3.32
Hist 0.17
ATR (14)
1.83
4.15% of price
Realised vol 30D
44.6%
Annualised
Bollinger upper
54.74
20, 2σ
Bollinger lower
38.72
20, 2σ
50 / 200 cross
Death
53.41 vs 70.05
Trend bias
Below 200
-37.19%

Options chain

Account required
Expiry
Spot 43.30
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.45
Less volatile than market
Correlation to SPY
0.14
Largely independent
Realised vol 30D
44.6%
Annualised
Market vol 1Y
13.0%
SPY, annualised
Max drawdown 1Y
-49.7%
Peak to trough
Max drawdown 5Y
-52.4%
Peak to trough
ATR 14
1.83
4.15% of price
Beta (reported)
0.38
5Y monthly, from filing

Short interest

Semi-monthly exchange report · lags by ~2 weeks
Shares short
20.89M
Prior 20.91M
Change vs prior
-0.1%
Shorts covering
% of float
16.65%
Elevated
% of shares out
12.57%
Against total outstanding
Days to cover
6.6
Crowded exit
Float
164.82M
Freely tradeable shares

Exchanges publish short interest twice a month with a settlement lag, so this is roughly two weeks behind. Days to cover divides shares short by average daily volume — it estimates how long covering would take, not whether it will happen.

Rating changes

271 on file
DateFirm ActionFromTo
Sep 24, 26 HC Wainwright & Co. MAINTAINED Buy Buy
Sep 22, 26 JP Morgan MAINTAINED Overweight Overweight
Sep 15, 26 Guggenheim MAINTAINED Buy Buy
Sep 9, 26 Barclays MAINTAINED Overweight Overweight
Sep 8, 26 Morgan Stanley MAINTAINED Overweight Overweight
Sep 8, 26 Goldman Sachs MAINTAINED Neutral Neutral
Sep 8, 26 BMO Capital MAINTAINED Market Perform Market Perform
Sep 8, 26 Canaccord Genuity MAINTAINED Buy Buy
Sep 8, 26 HC Wainwright & Co. MAINTAINED Buy Buy
Sep 4, 26 Needham MAINTAINED Buy Buy
Sep 4, 26 BMO Capital MAINTAINED Market Perform Market Perform
Sep 4, 26 HC Wainwright & Co. MAINTAINED Buy Buy

Dividends & splits

Declared · from the issuer
Forward rate—
Forward yield0.00%
5-year avg yield—
Payout ratio0.00%
Ex-dividend date—
Next pay date—
Last split—
Split date—

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.