AGIO

Agios Pharmaceuticals, Inc.
NasdaqGSUSDEQUITY Healthcare DELAYED
Last price
33.09
▼ 0.54 (1.61%)
MARKET ·

Price

Open
33.75
Prev close
33.63
Day high
34.08
Day low
32.95
Volume
558.98K
Market cap
$1.98B
P/E (TTM)
52W range
22.24 – 46.00

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
-1.40% -0.0%
1M
-8.79% -12.5%
3M
+14.94% +11.8%
6M
+13.13% +2.1%
YTD
+21.57% +9.3%
1Y
-10.13% -30.1%
3Y
+23.93% -50.2%
5Y

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Fundamentals

TTM · reported
Market cap$1.98B
Enterprise value$1.39B
Revenue (TTM)$98.34M
Gross profit$-266.29M
EBITDA$-453.67M
Net income$-411.29M
EPS (TTM)$-7.01
Free cash flow$-274.60M
Total cash$617.58M
Total debt$31.17M
Book value / share$17.21
Shares outstanding59.70M
Float50.02M
Short % of float11.58%
Dividend yield
Beta (5Y)0.59

Valuation & profitability ratios

Account required
Trailing P/E
Forward P/E-8.38
PEG ratio
Price / sales
Price / book1.92
EV / revenue14.13
EV / EBITDA-3.06
Gross margin-270.79%
Operating margin-247.07%
Profit margin0.00%
Return on equity-34.34%
Return on assets-22.24%
Debt / equity3.04
Current ratio10.22
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

Annual · as reported
Last 4 fiscal years
Line item2025202420232022
Total revenue$54.03M$36.50M$26.82M$14.24M
Cost of revenue$0$0$0$0
Gross profit$0$0$0$0
R&D
SG&A
Operating income
Pre-tax income
Tax provision$0$0$0$0
Net income-$412.78M$673.73M-$352.09M-$231.80M
EBIT$0$0$0$0

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 -1.67-1.69 -1.5%
Mar 2026 -1.79-1.69 +5.7%
Dec 2025 -1.95-1.85 +4.9%
Sep 2025 -1.90-1.78 +6.5%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter -1.19 8 $53.76M +317.4%
Next quarter -1.08 10 $63.20M +216.5%
Current year -5.63 8 $182.49M +237.8%
Next year -3.69 10 $351.51M +92.6%

Analyst targets & ownership

Account required
Mean target$45.75
High target$73.00
Low target$32.00
Implied upside38.26%
Analyst count8
ConsensusBUY
Strong buy / Buy0 / 7
Hold3
Sell / Strong sell0 / 0
Held by insiders1.07%
Held by institutions112.34%
Institutions holding321
Free account required

Price targets, consensus spread, insider and institutional ownership.

Insider net activity

6m · Form 4 rollup
Net shares
+171.52K
Net buying
Buy transactions
32
285.86K shares
Sell transactions
16
114.34K shares
Net transactions
+48
Buys less sells
Sell : buy shares
0.4 : 1
Mixed
Insider-held shares
637.62K
Total on file
Bought 285.86KSold 114.34K

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Aug 4, 26
GHEUENS SARAH
Officer
SELL 30.00K $914.40K Direct
Jul 8, 26
BACKSTROM JAY T
Director
STOCK 1.45K $0 Direct
Jul 8, 26
BACKSTROM JAY T
Director
CONVERSION 1.45K $61.87K Direct
Jul 1, 26
GHEUENS SARAH
Officer
SELL 4.01K $150.50K Direct
Jul 1, 26
GHEUENS SARAH
Officer
8.38K Direct
Jun 18, 26
HO MAYKIN
Director
2.82K Direct
Jun 18, 26
SCADDEN DAVID T.
Director
2.82K Direct
Jun 18, 26
BALLAL RAHUL D.
Director
2.82K Direct
Jun 18, 26
ADAMS CATHERINE OWEN
Director
2.82K Direct
Jun 18, 26
JONES CECILIA
Chief Financial Officer
CONVERSION 3.00K $102.48K Direct
Jun 18, 26
SMITH CYNTHIA
Director
2.82K Direct
Jun 18, 26
GOFF BRIAN
Chief Executive Officer
CONVERSION 39.00K $1.33M Direct
Jun 18, 26
CAPELLO JEFFREY D
Director
2.82K Direct
Jun 18, 26
FOSTER-CHEEK KAYE I
Director
2.82K Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

10 reporting
NameRelationShares heldLatest
ADAMS CATHERINE OWEN
Director 10.87K Conversion of Exercise of derivative security
BACKSTROM JAY T
Director 1.45K Stock Award(Grant)
BALLAL RAHUL D.
Director 15.23K Conversion of Exercise of derivative security
CAPELLO JEFFREY D
Director 10.87K Conversion of Exercise of derivative security
FOSTER-CHEEK KAYE I
Director 12.48K Conversion of Exercise of derivative security
FOUSE JACQUALYN A.
Director 154.16K Conversion of Exercise of derivative security
GHEUENS SARAH
Officer 54.65K Sale
HO MAYKIN
Director 19.85K Conversion of Exercise of derivative security
SCADDEN DAVID T.
Director 20.42K Conversion of Exercise of derivative security
SMITH CYNTHIA
Director 15.23K Conversion of Exercise of derivative security

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
33.64
-1.63% from price
SMA 20
33.26
-0.51% from price
SMA 50
35.56
-6.95% from price
SMA 100
32.47
+1.90% from price
SMA 200
30.93
+6.99% from price
EMA 12
33.67
-1.74% from price
EMA 26
34.16
-3.12% from price
EMA 50
34.07
-2.87% from price
RSI (14)
44.7
Neutral
MACD (12,26,9)
-0.48
Hist 0.18
ATR (14)
1.32
4.00% of price
Realised vol 30D
48.3%
Annualised
Bollinger upper
36.64
20, 2σ
Bollinger lower
29.88
20, 2σ
50 / 200 cross
Golden
35.56 vs 30.93
Trend bias
Above 200
+6.99%

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.54
Less volatile than market
Correlation to SPY
0.09
Largely independent
Realised vol 30D
48.3%
Annualised
Market vol 1Y
12.9%
SPY, annualised
Max drawdown 1Y
-50.9%
Peak to trough
Max drawdown 5Y
-65.7%
Peak to trough
ATR 14
1.32
4.00% of price
Beta (reported)
0.59
5Y monthly, from filing

Unusual options activity

Account required
Flagged1
Total notional$82.80K
Call notional$0
Put notional$82.80K
Tiltput-weighted
Likely opening0 of 1
SideStrikeExpiryVolumeOpen int. Vol / OINotionalIV PrintScore
PUT 30.00 Nov 20, 26
89d
300 334 0.9× $82.80K 73% at bid
43
How this is calculated, and what it cannot see

A contract is flagged when today's volume approaches or exceeds its open interest, the position is worth at least $40,000, and at least 150 contracts changed hands. Open interest is what was outstanding at yesterday's close, so volume above it means the flow cannot all be closing — something is being opened.

The score weights four things: volume against open interest, dollar notional, volume against the rest of that chain, and where the last print sat inside the bid/ask spread.

What it cannot see. Volume here is a daily total, so ten small orders and one large one are indistinguishable — this is not block or sweep detection, which needs exchange-level time and sales. The print column compares the last trade to the current quote, which is a proxy for who was the aggressor, not a tagged flag. Quotes are delayed. A single large trade can be a hedge, a roll, or one leg of a spread, and none of those mean what a naked directional bet would mean.

Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Options analytics

Account required
Put / call volume
21.00
Put-heavy session
Put / call open interest
0.93
Positioning, not flow
Max pain
35.00
+5.8% from spot
ATM implied vol
51.4%
Nearest strike to spot
Skew (10% OTM)
+7.0%
Puts bid over calls
Call volume
11
Contracts, this expiry
Put volume
231
Contracts, this expiry
Heaviest call OI
40.00
103 contracts
Heaviest put OI
35.00
122 contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Options chain

Account required
ExpirySpot 33.09
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.