SNDX

Syndax Pharmaceuticals, Inc.
NasdaqGSUSDEQUITY Healthcare DELAYED
Last price
19.65
▼ 0.10 (0.51%)
MARKET ·

Price

Open
19.38
Prev close
19.75
Day high
20.25
Day low
19.25
Volume
1.36M
Market cap
$1.75B
P/E (TTM)
52W range
12.99 – 25.59

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
-0.96% +0.4%
1M
-7.36% -11.1%
3M
-0.61% -3.7%
6M
-0.20% -11.3%
YTD
-6.47% -18.8%
1Y
+24.84% +4.8%
3Y
+9.17% -65.0%
5Y

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Fundamentals

TTM · reported
Market cap$1.75B
Enterprise value$1.79B
Revenue (TTM)$252.25M
Gross profit$-20.20M
EBITDA$-194.16M
Net income$-220.76M
EPS (TTM)$-2.51
Free cash flow$-150.08M
Total cash$554.27M
Total debt$589.38M
Book value / share$0.17
Shares outstanding89.30M
Float80.30M
Short % of float25.82%
Dividend yield
Beta (5Y)0.37

Valuation & profitability ratios

Account required
Trailing P/E
Forward P/E-24.08
PEG ratio
Price / sales
Price / book116.27
EV / revenue7.10
EV / EBITDA-9.22
Gross margin-8.01%
Operating margin-54.95%
Profit margin-87.52%
Return on equity-255.93%
Return on assets-18.67%
Debt / equity3,903.45
Current ratio6.77
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

Annual · as reported
Last 4 fiscal years
Line item2025202420232022
Total revenue$172.35M$23.68M$0$0
Cost of revenue$0$0$0$0
Gross profit$0$0$0$0
R&D
SG&A
Operating income
Pre-tax income
Tax provision$0$0$0$0
Net income-$285.42M-$318.76M-$209.36M-$149.34M
EBIT$0$0$0$0

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 -0.44-0.55 -26.0%
Mar 2026 -0.59-0.48 +18.8%
Dec 2025 -0.58-0.78 -34.9%
Sep 2025 -0.71-0.70 +1.5%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter -0.47 10 $82.77M +80.4%
Next quarter -0.43 10 $96.49M +40.4%
Current year -1.93 10 $315.40M +83.0%
Next year -0.74 11 $465.51M +47.6%

Analyst targets & ownership

Account required
Mean target$37.91
High target$57.00
Low target$26.00
Implied upside92.92%
Analyst count11
ConsensusSTRONG BUY
Strong buy / Buy2 / 10
Hold0
Sell / Strong sell0 / 0
Held by insiders1.69%
Held by institutions126.14%
Institutions holding343
Free account required

Price targets, consensus spread, insider and institutional ownership.

Insider net activity

6m · Form 4 rollup
Net shares
-19.79K
Net selling
Buy transactions
2
86.13K shares
Sell transactions
4
105.91K shares
Net transactions
+6
Buys less sells
Sell : buy shares
1.2 : 1
Mixed
Insider-held shares
1.51M
Total on file
Bought 86.13KSold 105.91K

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Jul 8, 26
METZGER MICHAEL A
Chief Executive Officer
SELL 32.38K $784.78K Direct
Jul 8, 26
METZGER MICHAEL A
Chief Executive Officer
CONVERSION 32.38K $206.55K Direct
Jun 12, 26
BOTWOOD NICHOLAS A.J.
Officer
SELL 65.52K $1.18M Direct
Jun 12, 26
BOTWOOD NICHOLAS A.J.
Officer
CONVERSION 53.75K $742.83K Direct
Jun 1, 26
GOLDAN KEITH ALAN
Chief Financial Officer
SELL 1.18K $22.35K Direct
Jun 1, 26
METZGER MICHAEL A
Chief Executive Officer
SELL 6.85K $130.03K Direct
Feb 9, 26
GOLDAN KEITH ALAN
Chief Financial Officer
SELL 3.41K $71.70K Direct
Feb 9, 26
METZGER MICHAEL A
Chief Executive Officer
SELL 17.16K $360.82K Direct
Feb 6, 26
GOLDAN KEITH ALAN
Chief Financial Officer
SELL 2.08K $42.93K Direct
Feb 6, 26
METZGER MICHAEL A
Chief Executive Officer
SELL 7.41K $152.84K Direct
Feb 4, 26
PODLESAK DENNIS G
Director
STOCK 48.00K $0 Direct
Feb 4, 26
KATKIN KEITH A
Director
STOCK 24.00K $0 Direct
Feb 4, 26
LEGAULT PIERRE
Director
STOCK 24.00K $0 Direct
Feb 4, 26
GOLDAN KEITH ALAN
Chief Financial Officer
STOCK 52.25K $0 Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

10 reporting
NameRelationShares heldLatest
BOTWOOD NICHOLAS A.J.
Officer 60.88K Sale
GALLAGHER NEIL
Officer 85.09K Sale
GOLDAN KEITH ALAN
Chief Financial Officer 139.25K Sale
HUBER MARTIN H JR
Director 103.00K Stock Award(Grant)
JARRETT A JENNIFER
Director 114.00K Stock Award(Grant)
KATKIN KEITH A
Director 124.00K Stock Award(Grant)
LEGAULT PIERRE
Director 114.00K Stock Award(Grant)
METZGER MICHAEL A
Chief Executive Officer 484.84K Sale
MEURY WILLIAM
Director 90.00K Stock Award(Grant)
PODLESAK DENNIS G
Director 239.76K Stock Award(Grant)

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
19.92
-1.37% from price
SMA 20
19.78
-0.64% from price
SMA 50
20.73
-5.21% from price
SMA 100
20.94
-6.18% from price
SMA 200
20.77
-5.41% from price
EMA 12
19.95
-1.52% from price
EMA 26
20.25
-2.96% from price
EMA 50
20.50
-4.14% from price
RSI (14)
45.0
Neutral
MACD (12,26,9)
-0.30
Hist 0.05
ATR (14)
1.03
5.26% of price
Realised vol 30D
43.1%
Annualised
Bollinger upper
20.76
20, 2σ
Bollinger lower
18.80
20, 2σ
50 / 200 cross
Death
20.73 vs 20.77
Trend bias
Below 200
-5.41%

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.63
Less volatile than market
Correlation to SPY
0.16
Largely independent
Realised vol 30D
43.1%
Annualised
Market vol 1Y
12.9%
SPY, annualised
Max drawdown 1Y
-32.6%
Peak to trough
Max drawdown 5Y
-69.9%
Peak to trough
ATR 14
1.03
5.26% of price
Beta (reported)
0.37
5Y monthly, from filing

Unusual options activity

Account required
Flagged1
Total notional$42.30K
Call notional$42.30K
Put notional$0
Tiltcall-weighted
Likely opening1 of 1
SideStrikeExpiryVolumeOpen int. Vol / OINotionalIV PrintScore
CALL 25.00 Nov 20, 26
89d
282 121 2.3× $42.30K 96% at bid
52
How this is calculated, and what it cannot see

A contract is flagged when today's volume approaches or exceeds its open interest, the position is worth at least $40,000, and at least 150 contracts changed hands. Open interest is what was outstanding at yesterday's close, so volume above it means the flow cannot all be closing — something is being opened.

The score weights four things: volume against open interest, dollar notional, volume against the rest of that chain, and where the last print sat inside the bid/ask spread.

What it cannot see. Volume here is a daily total, so ten small orders and one large one are indistinguishable — this is not block or sweep detection, which needs exchange-level time and sales. The print column compares the last trade to the current quote, which is a proxy for who was the aggressor, not a tagged flag. Quotes are delayed. A single large trade can be a hedge, a roll, or one leg of a spread, and none of those mean what a naked directional bet would mean.

Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Options analytics

Account required
Put / call volume
1.96
Put-heavy session
Put / call open interest
1.53
Positioning, not flow
Max pain
22.00
+12.0% from spot
ATM implied vol
54.5%
Nearest strike to spot
Skew (10% OTM)
+2.5%
Puts bid over calls
Call volume
67
Contracts, this expiry
Put volume
131
Contracts, this expiry
Heaviest call OI
22.00
400 contracts
Heaviest put OI
20.00
1.01K contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Options chain

Account required
ExpirySpot 19.65
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.