KPTI

Karyopharm Therapeutics Inc.
NasdaqGSUSDEQUITY Healthcare DELAYED
Last price
0.68
▲ 0.01 (1.42%)
MARKET · —

Price

1D — H — L — Range — Vol —
Drag pan · Pinch zoom · Hold crosshair · pick a tool then drag to draw
Open
0.67
Prev close
0.67
Day high
0.72
Day low
0.64
Volume
1.18M
Market cap
$14.74M
P/E (TTM)
—
52W range
0.63 – 10.99

Day trading desk

Current session · delayed
Gap from prior close
-0.00%
Prior close 0.67
VWAP
0.67
+0.96% from price
Relative volume
0.71×
Normal
Session range
12.56%
0.64 – 0.71
Position in range
56%
Mid range
ATR (14D)
0.18
26.84% of price
Prior day high
0.80
PDH
Prior day low
0.63
PDL
Bid / ask spread
—
Quote not published
Session volume
1.21M
Avg 1.71M

VWAP and the session figures are computed from the delayed intraday series on this page, so they lag the live tape and will not match a broker's real-time VWAP exactly. Turn on Prior day H/L/C, Opening range and Volume profile in the chart's Studies menu to see these levels drawn on price.

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
-46.06% -48.0%
1M
-63.69% -64.8%
3M
-93.91% -98.4%
6M
-90.98% -109.2%
YTD
-91.17% -105.4%
1Y
-89.81% -106.2%
3Y
-96.77% -179.0%
5Y
— —

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Unusual options activity

Account required
Nothing crossed the thresholds in the expiries we scanned.
That is the normal state — most contracts trade well inside their existing open interest.
Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Free account

5 more panels on KPTI open with an account.

Options chains and analytics, valuation ratios, insider filings, analyst targets and ownership. No card, no trial, nothing to cancel.

Insider net activity

6m · Form 4 rollup
Net shares
+97.27K
Net buying
Buy transactions
12
101.58K shares
Sell transactions
9
4.31K shares
Net transactions
+21
Buys less sells
Sell : buy shares
0.0 : 1
Mixed
Insider-held shares
1.06M
Total on file
Bought 101.58KSold 4.31K

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Sep 1, 26
ABATE KRISTIN
Officer
SELL 19 $38 Direct
Jul 28, 26
POULTON STUART
Officer
SELL 189 $1.34K Direct
May 21, 26
BOHLIN GAREN G.
Director
STOCK 15.51K $0 Direct
May 21, 26
OLIGER CHRISTY J
Director
STOCK 15.51K $0 Direct
May 21, 26
SU ZHEN
Director
STOCK 15.51K $0 Direct
May 21, 26
GREENE BARRY E
Director
STOCK 15.51K $0 Direct
May 21, 26
PAKIANATHAN DEEPIKA R
Director
STOCK 15.51K $0 Direct
May 21, 26
SCHOR CHEN
Director
STOCK 15.51K $0 Direct
May 14, 26
PAULSON RICHARD A.
Chief Executive Officer
SELL 2.20K $20.93K Direct
May 14, 26
RANGWALA RESHMA
Officer
SELL 408 $3.88K Direct
May 14, 26
MANO MICHAEL
Officer
SELL 266 $2.53K Direct
May 14, 26
CHENG SOHANYA ROSHAN
Officer
SELL 324 $3.08K Direct
May 14, 26
POULTON STUART
Officer
SELL 403 $3.83K Direct
May 14, 26
ABATE KRISTIN
Officer
SELL 53 $504 Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

10 reporting
NameRelationShares heldLatest
ABATE KRISTIN
Officer 23.78K Sale
BOHLIN GAREN G.
Director 18.52K Stock Award(Grant)
CHENG SOHANYA ROSHAN
Officer 107.94K Sale
GREENE BARRY E
Director 16.41K Stock Award(Grant)
MACOMBER LORI A
Chief Financial Officer 85.11K Sale
MANO MICHAEL
Officer 94.40K Sale
PAKIANATHAN DEEPIKA R
Director 15.51K Stock Award(Grant)
PAULSON RICHARD A.
Chief Executive Officer 269.75K Sale
POULTON STUART
Officer 94.63K Sale
RANGWALA RESHMA
Officer 56.83K Sale

Fundamentals

TTM · reported
Market cap$14.74M
Enterprise value$278.17M
Revenue (TTM)$146.62M
Gross profit$145.25M
EBITDA$-82.20M
Net income$-224.74M
EPS (TTM)$-13.93
Free cash flow$-29.67M
Total cash$65.11M
Total debt$328.53M
Book value / share$-14.56
Shares outstanding22.68M
Float16.01M
Short % of float34.85%
Dividend yield0.00%
Beta (5Y)1.04

Valuation & profitability ratios

Account required
Trailing P/E—
Forward P/E-0.23
PEG ratio—
Price / sales—
Price / book—
EV / revenue1.90
EV / EBITDA-3.38
Gross margin99.06%
Operating margin-67.38%
Profit margin-153.28%
Return on equity—
Return on assets-47.61%
Debt / equity—
Current ratio0.79
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

As reported · 5 years · 5 quarters
Blank means not reported, not zero
Line item2025202420232022YoY
Total revenue $146.07M$145.24M$146.03M$157.07M +0.6%
Operating revenue $146.07M$145.24M$146.03M$157.07M +0.6%
Cost of revenue $5.95M$6.01M$4.94M$5.21M -1.0%
Gross profit $140.12M$139.23M$141.09M$151.86M +0.6%
Research & development $125.62M$143.23M$138.75M$148.66M -12.3%
Selling, general & admin $105.21M$115.44M$131.88M$145.40M -8.9%
Total operating expense $230.82M$258.67M$270.63M$294.06M -10.8%
Operating income -$90.71M-$119.44M-$129.54M-$142.20M +24.1%
Net interest income -$43.08M-$30.02M-$12.88M-$22.64M -43.5%
Pre-tax income -$196.00M-$76.36M-$142.78M-$164.92M -156.7%
Tax provision $43.00K$57.00K$323.00K$369.00K -24.6%
Net income -$196.04M-$76.42M-$143.10M-$165.29M -156.5%
Net income to common -$196.04M-$76.42M-$143.10M-$165.29M -156.5%
Basic EPS -17.93-9.45-18.79-30.30 -89.7%
Diluted EPS -17.93-13.95-18.79-30.30 -28.5%
EBIT -$150.15M-$38.94M-$118.95M-$139.93M -285.6%
EBITDA -$149.85M-$38.60M-$118.42M-$139.31M -288.2%
Basic shares 10.94M8.12M7.62M5.46M +34.6%
Diluted shares 10.94M8.45M7.62M5.46M +29.3%

Options analytics

Account required
Put / call volume
1.63
Put-heavy session
Put / call open interest
—
Positioning, not flow
Max pain
0.50
-23.1% from spot
ATM implied vol
0.0%
Nearest strike to spot
Skew (10% OTM)
+50.0%
Puts bid over calls
Call volume
38
Contracts, this expiry
Put volume
62
Contracts, this expiry
Heaviest call OI
0.50
0 contracts
Heaviest put OI
0.50
0 contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 -1.39-2.32 -66.9%
Mar 2026 -1.44-1.24 +14.1%
Dec 2025 -2.00-2.23 -11.4%
Sep 2025 -3.25-3.82 -17.5%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter -1.32 2 $33.54M -23.8%
Next quarter -1.21 2 $34.31M +0.7%
Current year -5.85 2 $135.63M -7.1%
Next year -2.82 2 $173.57M +28.0%

Analyst targets & ownership

Account required
Mean target$7.25
High target$11.00
Low target$3.00
Implied upside966.18%
Analyst count4
ConsensusNONE
Strong buy / Buy2 / 2
Hold1
Sell / Strong sell0 / 0
Held by insiders4.67%
Held by institutions97.03%
Institutions holding136
Free account required

Price targets, consensus spread, insider and institutional ownership.

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
1.21
-43.96% from price
SMA 20
1.46
-55.55% from price
SMA 50
2.04
-68.19% from price
SMA 100
5.52
-87.68% from price
SMA 200
6.66
-90.24% from price
EMA 12
1.17
-41.75% from price
EMA 26
1.61
-57.85% from price
EMA 50
2.65
-74.33% from price
RSI (14)
17.4
Oversold
MACD (12,26,9)
-0.45
Hist -0.03
ATR (14)
0.18
28.08% of price
Realised vol 30D
147.3%
Annualised
Bollinger upper
2.26
20, 2σ
Bollinger lower
0.67
20, 2σ
50 / 200 cross
Death
2.04 vs 6.66
Trend bias
Below 200
-90.24%

Options chain

Account required
Expiry
Spot 0.68
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.58
Less volatile than market
Correlation to SPY
0.06
Largely independent
Realised vol 30D
147.3%
Annualised
Market vol 1Y
13.0%
SPY, annualised
Max drawdown 1Y
-93.9%
Peak to trough
Max drawdown 5Y
-99.7%
Peak to trough
ATR 14
0.18
28.08% of price
Beta (reported)
1.04
5Y monthly, from filing

Short interest

Semi-monthly exchange report · lags by ~2 weeks
Shares short
7.87M
Prior 9.64M
Change vs prior
-18.4%
Shorts covering
% of float
34.85%
Heavily shorted
% of shares out
34.68%
Against total outstanding
Days to cover
6.0
Crowded exit
Float
16.01M
Freely tradeable shares

Exchanges publish short interest twice a month with a settlement lag, so this is roughly two weeks behind. Days to cover divides shares short by average daily volume — it estimates how long covering would take, not whether it will happen.

Rating changes

127 on file
DateFirm ActionFromTo
Jul 31, 26 Piper Sandler MAINTAINED Overweight Overweight
Jul 31, 26 HC Wainwright & Co. DOWNGRADE Buy Neutral
May 6, 26 HC Wainwright & Co. MAINTAINED Buy Buy
Apr 27, 26 Piper Sandler MAINTAINED Overweight Overweight
Mar 30, 26 Piper Sandler MAINTAINED Overweight Overweight
Mar 25, 26 Baird MAINTAINED Outperform Outperform
Mar 25, 26 HC Wainwright & Co. MAINTAINED Buy Buy
Mar 10, 26 Rodman & Renshaw INITIATED — Buy
Feb 18, 26 HC Wainwright & Co. MAINTAINED Buy Buy
Feb 5, 26 Cantor Fitzgerald INITIATED — Overweight
Nov 4, 25 RBC Capital MAINTAINED Outperform Outperform
Oct 13, 25 HC Wainwright & Co. UPGRADE Neutral Buy

Dividends & splits

Declared · from the issuer
Forward rate—
Forward yield0.00%
5-year avg yield—
Payout ratio—
Ex-dividend date—
Next pay date—
Last split1:15
Split dateFeb 26, 2025

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.