GPCR

Structure Therapeutics Inc.
NasdaqGMUSDEQUITY Healthcare DELAYED
Last price
49.20
▼ 1.32 (2.61%)
MARKET ·

Price

Open
51.51
Prev close
50.52
Day high
51.11
Day low
49.01
Volume
592.48K
Market cap
$3.50B
P/E (TTM)
52W range
18.26 – 94.90

Trailing performance

Price return · vs SPY
Returnvs SPY
1W
-9.94% -8.6%
1M
-3.37% -7.1%
3M
+26.55% +23.5%
6M
-26.24% -37.3%
YTD
-29.42% -41.7%
1Y
+164.42% +144.4%
3Y
+81.28% +7.1%
5Y

Price return only. Dividends are not reinvested, so total return on a dividend payer will be higher than shown.

Fundamentals

TTM · reported
Market cap$3.50B
Enterprise value$2.16B
Revenue (TTM)
Gross profit
EBITDA$-265.79M
Net income$-214.84M
EPS (TTM)$-3.03
Free cash flow$-119.06M
Total cash$1.34B
Total debt$6.23M
Book value / share$19.02
Shares outstanding71.31M
Float54.64M
Short % of float11.67%
Dividend yield
Beta (5Y)-1.51

Valuation & profitability ratios

Account required
Trailing P/E
Forward P/E-23.21
PEG ratio
Price / sales
Price / book2.58
EV / revenue
EV / EBITDA-8.14
Gross margin0.00%
Operating margin0.00%
Profit margin0.00%
Return on equity-20.21%
Return on assets-14.95%
Debt / equity0.46
Current ratio20.75
Free account required

Fourteen ratios including P/E, PEG, EV/EBITDA, margins and return on equity.

Financial statements

Annual · as reported
Last 4 fiscal years
Line item2025202420232022
Total revenue$0$0$0$0
Cost of revenue$0$0$0$0
Gross profit$0$0$0$0
R&D
SG&A
Operating income
Pre-tax income
Tax provision$0$0$0$0
Net income-$141.20M-$122.53M-$89.62M-$52.84M
EBIT$0$0$0$0

Earnings

History & consensus estimates
Reported vs expected · EPS
QuarterEst.ActualSurprise
Jun 2026 -0.38-0.49 -28.3%
Mar 2026 -0.31-0.35 -12.9%
Dec 2025 -0.370.20 +154.2%
Sep 2025 -0.37-0.37 -0.6%
Forward consensus
PeriodEPSAnalystsRevenueGrowth
Current quarter -0.23 10 $50.00M 0.0%
Next quarter -0.49 10 $0 0.0%
Current year -1.62 12 $38.46M 0.0%
Next year -2.19 10 $41.67K -99.9%

Analyst targets & ownership

Account required
Mean target$104.77
High target$145.00
Low target$69.50
Implied upside112.94%
Analyst count15
ConsensusSTRONG BUY
Strong buy / Buy4 / 11
Hold1
Sell / Strong sell0 / 0
Held by insiders2.85%
Held by institutions97.67%
Institutions holding267
Free account required

Price targets, consensus spread, insider and institutional ownership.

Insider net activity

6m · Form 4 rollup
Net shares
0
Net selling
Buy transactions
0
0 shares
Sell transactions
0
Net transactions
0
Buys less sells
Sell : buy shares
Not enough filings
Insider-held shares
2.03M
Total on file

Insider transactions

Account required
DateInsiderAction SharesValueHeld
Aug 18, 26
LIN XICHEN
Officer
CONVERSION 11.82K $4.02K Direct
Aug 6, 26
BERRIOS JOHN JOSEPH
Officer
STOCK 140.77K $0 Direct
Aug 4, 26
LIN XICHEN
Officer
CONVERSION 11.82K $4.02K Direct
Jul 14, 26
LIN XICHEN
Officer
CONVERSION 23.63K $1.20M Direct
Jun 25, 26
LIN XICHEN
Officer
CONVERSION 23.63K $8.04K Direct
Apr 15, 26
LANG MATTHEW
Chief Operating Officer
STOCK 184.61K $0 Direct
Mar 19, 26
STEVENS RAYMOND C
Chief Executive Officer
STOCK 260.22K $0 Direct
Mar 19, 26
HALL ASHLEY
Officer
STOCK 47.71K $0 Direct
Mar 19, 26
MA YINGLI
Chief Technology Officer
STOCK 32.53K $0 Direct
Mar 19, 26
LIN XICHEN
Officer
STOCK 43.37K $0 Direct
Mar 19, 26
YOON JUN
Chief Financial Officer
STOCK 104.08K $0 Direct
Mar 19, 26
COLL CRESPO BLAS
Officer
STOCK 75.90K $0 Direct
Jul 1, 25
STEVENS RAYMOND C
Chief Executive Officer
STOCK 89.70K $0 Direct
Jul 1, 25
MA YINGLI
Chief Technology Officer
STOCK 24.46K $0 Direct
What this is, and what it is not

These are SEC Form 4 filings — officers, directors and 10% owners reporting their own trades in the company's stock. Filing is due within two business days of the transaction, so this lags reality by days, and the provider adds its own lag on top.

A sale is not automatically bearish. Executives sell on scheduled 10b5-1 plans, to cover tax on vesting equity, and to diversify. Purchases with cash are generally the more informative signal, and they are far rarer.

This does not include congressional or senate trading. That comes from STOCK Act disclosures filed with the Senate eFD system and the House Clerk, which this data source does not carry.

Free account required

Officer and director trades in their own stock, straight from Form 4 filings.

Insider holders

8 reporting
NameRelationShares heldLatest
BERRIOS JOHN JOSEPH
Officer 140.77K Stock Award(Grant)
COLL CRESPO BLAS
Officer 280.88K Stock Award(Grant)
HALL ASHLEY
Officer 155.19K Stock Award(Grant)
LANG MATTHEW
Chief Operating Officer 184.61K Stock Award(Grant)
LIN XICHEN
Officer 228.96K Conversion of Exercise of derivative security
MA YINGLI
Chief Technology Officer 139.92K Stock Award(Grant)
STEVENS RAYMOND C
Chief Executive Officer 2.96M Stock Award(Grant)
YOON JUN
Chief Financial Officer 2.96M Stock Award(Grant)

Moving averages & technicals

Computed from 2Y daily closes
SMA 10
53.01
-7.18% from price
SMA 20
51.29
-4.29% from price
SMA 50
50.07
-1.96% from price
SMA 100
46.90
+4.90% from price
SMA 200
53.70
-8.58% from price
EMA 12
52.03
-5.44% from price
EMA 26
51.27
-4.03% from price
EMA 50
49.98
-1.56% from price
RSI (14)
43.5
Neutral
MACD (12,26,9)
0.76
Hist -0.34
ATR (14)
2.60
5.30% of price
Realised vol 30D
49.8%
Annualised
Bollinger upper
56.30
20, 2σ
Bollinger lower
46.28
20, 2σ
50 / 200 cross
Death
50.07 vs 53.70
Trend bias
Below 200
-8.58%

Risk profile

Daily returns · 1Y window
Beta vs SPY
0.85
Less volatile than market
Correlation to SPY
0.09
Largely independent
Realised vol 30D
49.8%
Annualised
Market vol 1Y
12.9%
SPY, annualised
Max drawdown 1Y
-61.7%
Peak to trough
Max drawdown 5Y
-81.0%
Peak to trough
ATR 14
2.60
5.30% of price
Beta (reported)
-1.51
5Y monthly, from filing

Unusual options activity

Account required
Flagged1
Total notional$52.80K
Call notional$52.80K
Put notional$0
Tiltcall-weighted
Likely opening1 of 1
SideStrikeExpiryVolumeOpen int. Vol / OINotionalIV PrintScore
CALL 57.50 Sep 18, 26
26d
240 20 12.0× $52.80K 85% at ask
72
How this is calculated, and what it cannot see

A contract is flagged when today's volume approaches or exceeds its open interest, the position is worth at least $40,000, and at least 150 contracts changed hands. Open interest is what was outstanding at yesterday's close, so volume above it means the flow cannot all be closing — something is being opened.

The score weights four things: volume against open interest, dollar notional, volume against the rest of that chain, and where the last print sat inside the bid/ask spread.

What it cannot see. Volume here is a daily total, so ten small orders and one large one are indistinguishable — this is not block or sweep detection, which needs exchange-level time and sales. The print column compares the last trade to the current quote, which is a proxy for who was the aggressor, not a tagged flag. Quotes are delayed. A single large trade can be a hedge, a roll, or one leg of a spread, and none of those mean what a naked directional bet would mean.

Free account required

Contracts trading at or above their open interest, ranked by notional and where the print landed.

Options analytics

Account required
Put / call volume
0.14
Call-heavy session
Put / call open interest
0.32
Positioning, not flow
Max pain
47.50
-3.2% from spot
ATM implied vol
78.5%
Nearest strike to spot
Skew (10% OTM)
-12.8%
Calls bid over puts
Call volume
321
Contracts, this expiry
Put volume
46
Contracts, this expiry
Heaviest call OI
60.00
88 contracts
Heaviest put OI
45.00
33 contracts

Max pain is the strike at which the largest dollar value of open contracts expires worthless. It describes current positioning; it is not a forecast and it moves as open interest changes.

Free account required

Put/call ratios, max pain, implied volatility skew and where open interest is concentrated.

Options chain

Account required
ExpirySpot 49.20
Calls
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Puts
StrikeLastBidAskVolOIIV
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
000.000.000.000.00000.0%
Free account required

Every listed expiry, both sides of the book, with volume, open interest and implied volatility.

PRIVATE STRATEGY · BY QUALIFICATION

The same data. A different seat.

The research you are reading is the input layer for a discretionary options program we run for a small number of qualified investors. Minimum $1,000,000.